Polyprenols


Polyprenols is one of the polyisoprenoids naturally occurring in plants. These are non-saturated polyisoprenoid alcohols extracted from SPRUCE needles.

 

Used as an ingredient in food production, pharmaceutical and cosmetics, and other industries.

In products:



Polyprenols are metabolised to dolichols and dolichol phosphates in liver. Malfunctioning of dolichol phosphates cycle is observed in ageing processes and in cases of various pathologies and metabolism disorders.

In recent years the ability of polyprenols to increase the muscle and heart strength and to reduce the side effects caused by statins has been studied actively.

 

[1] Rip, Jack W., et al. "Distribution, metabolism and function of dolichol and polyprenols." Progress in lipid research 24.4 (1985): 269-309.

[2] Jansone, B., Dzirkale, Z., Jekabsons, K., Pilipenko, V., Beitnere, U., Skumbins, R., Kletnieks, K., Vanaga, I., Muceniece, R., Klusa, V. (IUPHAR 2015). Polyprenols isolated from Picea abies L. Spruce needles influence atorvastatin-mediated muscle strength weakness in

Wistar female rats. Chin. J. Pharmacol. Toxicol, 29 (1), 113

[3] Latkovskis, G., Saripo, V., Sokolova, E., Upite, D., Vanaga, I., Kletnieks, U., Erglis, A. (2016). Pilot study of safety and efficacy of polyprenols in combination with coenzyme Q10 in patients with statin-induced myopathy. Medicina 52 (3), 171-179